A bioreactor is a closed culture environment that has the capacity to control the biological processes and variables required for the proliferation of suitable cells in vitro. The bioreactor is based on the gas (oxygen, dissolved oxygen, nitrogen, carbon dioxide) in the cell and/or tissue culture medium, flow rate, glucose and pH values, and ambient temperature, etc. It closely monitors parameters that affect cell proliferation, such as, and aims to keep the growth rate of cells in culture at the highest level by immediately intervening in a possible environmental change.

The purpose of tissue engineering is; repairing cell-based tissues and improving their functions. The developments in tissue engineering in recent years have revealed the need for bioreactors that function in this regard. However, conventional bioreactors made of stainless steel or glass at clinical level cannot yet provide the necessary response to the production of three-dimensional (3D) functional tissue, which is the desired end product in tissue engineering, and they cannot be produced in 2 dimensions. remains limited. Another main problem of traditional bioreactors is that the sterilization process is very laborious and long and carries the risk of cross-contamination. These bioreactors allow the production of only one tissue at a time. Our project involves the design and production of the world’s first clinical-oriented, disposable bioreactor that can produce (more than one at a time) 3D bone, cartilage and simple soft and solid tissues. Validation of the system will be carried out following prototype production.